Search results for "Airway Remodelling"

showing 3 items of 3 documents

Airway remodelling assessed by sputum and high resolution computed tomography in asthma and COPD

2004

It is not known whether sputum elastase, metalloproteinase (MMP)-9 and tissue-inhibitor metalloproteinase (TIMP)-1 are related to structural changes of the airways, as assessed by high-resolution computed tomography (HRCT) scan. The relationships between these markers and the magnitude of structural changes of the airways in asthma and chronic obstructive pulmonary disease (COPD) were assessed. Induced sputum and HRCT scan were performed in 30 asthmatics (14 mild and 16 severe) and in 12 patients with COPD. A greater extent of HRCT scan abnormalities was found in COPD than in severe and mild asthmatics. HRCT scan abnormalities correlated with the degree of airway obstruction in COPD and in …

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyPathologyHigh-resolution computed tomographyairway inflammation imagingSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologyStatistics NonparametricPulmonary Disease Chronic ObstructiveInternal medicinemedicineHumansAirway RemodellingAgedAsthmaCOPDTissue Inhibitor of Metalloproteinase-1Pancreatic Elastasemedicine.diagnostic_testbusiness.industryElastaseRespiratory diseaseSputumMiddle Agedrespiratory systemAirway obstructionmedicine.diseaseAsthmaRespiratory Function Testsrespiratory tract diseasesMatrix Metalloproteinase 9SputumFemalemedicine.symptomTomography X-Ray Computedbusiness
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Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis

2006

The aim of the study was to investigate the expression of basic fibroblast growth factor (bFGF) and its receptor, fibroblast growth factor receptor (FGFR)-1, in the central airways of smokers with chronic bronchitis. The lobar bronchi from 17 subjects undergoing thoracotomy for solitary nodules were examined. All had a history of cigarette smoking, nine had symptoms of chronic bronchitis and airflow limitation, and eight were asymptomatic with normal lung function. Using immunohistochemical methods, bFGF and FGFR-1 expression in the total airway wall and the different airway compartments, i.e. bronchial glands, submucosal vessels and smooth muscle, was quantified. Moreover, to investigate t…

MalePulmonary and Respiratory MedicinePathologymedicine.medical_specialtyChronic bronchitisAngiogenesisBasic fibroblast growth factorFibroblast growth factorchemistry.chemical_compoundGrowth factor receptorCigarette smokingHumansMedicineAgedFibrolast growth factor receptor-1business.industryChronic obstructive pulmonary diseaseFibroblast growth factor receptor 1Smokingrespiratory systemmedicine.diseaseAirway remodelling; cigarette smoking; chronic obstructive pulmonary disease; fibroblast growth factor receptor-1Airway remodellingUp-Regulationrespiratory tract diseasesBronchitis ChronicchemistryFibroblast growth factor receptorBronchitisFemaleFibroblast Growth Factor 2Airway remodelling; Chronic obstructive pulmonary disease; Cigarette smoking; Fibrolast growth factor receptor-1;business
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Cellular network in airways inflammation and remodelling

2002

Chronic inflammation and airway remodelling are two key steps in asthma pathophysiology. The development of chronic airway inflammation depends upon the continuous recruitment of inflammatory cells from the bloodstream towards the bronchial mucosa and by their subsequent functional activation. The release of inflammatory mediators by activated cells contributes to the generation of a complex network which involves mobile inflammatory cells and structural cells such as epithelial cells, fibroblasts and myofibroblasts. This network is responsible for the amplification and persistence of the inflammatory process as well as for the development of a peculiar microenvironment which can directly m…

Pulmonary and Respiratory MedicineAdolescentCellInflammationmedicineHumansAirway RemodellingChildLungAsthmaInflammationbusiness.industryAirway inflammationBronchial mucosaInfantmedicine.diseasePathophysiologyAsthmarespiratory tract diseasesCell biologyAirway Obstructionmedicine.anatomical_structureInfant; Lung; Humans; Asthma; Child; Bronchial Hyperreactivity; Airway Obstruction; Adolescent; InflammationPediatrics Perinatology and Child HealthImmunologymedicine.symptomBronchial HyperreactivitybusinessMyofibroblastHuman
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